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Noticiario genética

            

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Headline (Posted) Abstract
New 'split-drive' system puts scientists in the (gene) driver seat (06 Mar 2021) New research describes novel achievements designed to make the implementation of gene drives safer and more controllable. The new split drive and home-and-rescue systems address concerns about the release of gene drives in wild populations.

New method facilitates development of antibody-based drugs (05 Mar 2021) In recent years, therapeutic antibodies have transformed the treatment of cancer and autoimmune diseases. Now, researchers have developed a new, efficient method based on the genetic scissors CRISPR-Cas9, that facilitates antibody development.

Tracking proteins in the heart of cells (05 Mar 2021)
The cell must provide its various organelles with all the energy elements they need, which are formed in the Golgi apparatus. But how do the proteins that carry these cargoes - the kinesins - find their way within the cell's ''road network'' to deliver them at the right place? Researchers have discovered a fluorescent chemical dye, making it possib [+]


Ancient DNA reveals clues about how tuberculosis shaped the human immune system (04 Mar 2021) A new study employing ancient human DNA reveals how tuberculosis has affected European populations over the past 2,000 years, specifically the impact that disease has had on the human genome. This work has implications for studying not only evolutionary genetics, but also how genetics can influence the immune system.

Protein discovery could help enable eco-friendly fungicides (04 Mar 2021) New research reveals an essential step in scientists' quest to create targeted, RNA-based, more eco-friendly fungicides that protect food crops.

New insights into an ancient protein complex (04 Mar 2021) Extensive collaboration between five VIB groups resulted in a better understanding of the machinery that plants use to regulate the protein composition of their outer membrane. This discovery enhances our basic knowledge of how the plasma membrane composition can be adapted based on external stimuli, an essential process for life on earth.

Scientists discover how microorganisms evolve cooperative behaviors (04 Mar 2021) New research sheds light on how interspecies interactions arise, evolve and are maintained. The results provide a new window to understand the key roles of these interactions in industrial applications, and in the health and disease of humans, animals and plants.

Fluorescent nanodiamonds successfully injected into living cells (03 Mar 2021)
As odd as it sounds, many scientists have attempted to place extremely small diamonds inside living cells. Why? Because nanodiamonds are consistently bright and can give us unique knowledge about the inner life of cells over a long time. Now physics researchers have succeeded in injecting a large number of nanodiamonds directly to the cell interior [+]


New search engine for single cell atlases (03 Mar 2021) A new software tool allows researchers to quickly query datasets generated from single-cell sequencing. Users can identify which cell types any combination of genes are active in. The open-access 'scfind' software enables swift analysis of multiple datasets containing millions of cells by a wide range of users, on a standard computer.

Key steps discovered in production of critical immune cell (03 Mar 2021)
Researchers have uncovered a process cells use to fight off infection and cancer that could pave the way for precision cancer immunotherapy treatment. Through gaining a better understanding of how this process works, researchers hope to be able to determine a way of tailoring immunotherapy to better fight cancer. This research lays the foundation f [+]


Vaccine shows signs of protection against dozen-plus flu strains (03 Mar 2021)
A vaccine candidate has demonstrated promising signs of protection against more than a dozen swine flu strains -- and more than a leading, commercially available vaccine. Its success in experiments involving swine suggests that its design could also fast-track efforts to develop a vaccine that protects people against many common strains of influenz [+]


Rice variety resists arsenic (02 Mar 2021) The agricultural cultivation of the staple food of rice harbors the risk of possible contamination with arsenic that can reach the grains following uptake by the roots. A research team studied over 4,000 rice variants and discovered a plant that resists the toxin as well as contains a large amount of the trace element selenium.

A new blindness gene uncovered in a canine study (02 Mar 2021) A study has uncovered a mutation in the IFT122 gene in blind dogs. The gene defect now discovered results in the progressive destruction of photoreceptor cells and retinal dystrophy. IFT122 is a new candidate also for retinal dystrophy in humans. A gene test in support of breeding and diagnostics has been developed based on the finding.

Bitter receptor involved in anti-inflammatory effect of resveratrol? (02 Mar 2021) At least in cell-based test systems, the plant compound resveratrol has anti-inflammatory properties. A recent collaborative study has now shown that the bitter receptor TAS2R50 is involved in this effect.

Division of labor within regenerating liver maintains metabolism, mouse study finds (02 Mar 2021)
The liver has a rare superpower among body organs - the ability to regenerate. It also keeps up its metabolic and toxin-removing work while regenerating, thanks to a subset of cells that expand their workload while the rest focus on multiplication, a new study in mice found. Furthermore, the cells of the liver communicate with each other to coordin [+]


A mechanism by which cells build 'mini-muscles' underneath their nucleus identified (02 Mar 2021)
Research has uncovered how motor protein myosin, which is responsible for contraction of skeletal muscles, functions also in non-muscle cells to build contractile structures at the inner face of the cell membrane. This is the first time when such 'mini-muscles', also known as stress fibers, have been seen to emerge spontaneously through myosin-driv [+]


Origin of life: The chicken-and-egg problem (02 Mar 2021) New research shows that slight alterations in transfer-RNA molecules (tRNAs) allow them to self-assemble into a functional unit that can replicate information exponentially. tRNAs are key elements in the evolution of early life-forms.

Common bacteria modified to make designer sugar-based drug (02 Mar 2021) Envisioning an animal-free drug supply, scientists have reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals.

Scientists use lipid nanoparticles to precisely target gene editing to the liver (01 Mar 2021) Scientists developed a highly efficient, targeted method for delivering gene editing machinery to specific tissues and organs, demonstrating the treatment of high cholesterol by targeting genes in the liver of mice, reducing cholesterol for over 3 months (and potentially more) with one treatment.

Velcro-like cellular proteins key to tissue strength (01 Mar 2021) Where do bodily tissues get their strength? New research provides important new clues to this long-standing mystery, identifying how specialized proteins called cadherins join forces to make cells stick -- and stay stuck -- together. The findings could lead to more life-like artificial tissues and tumor busting drugs.

How a plant regulates its growth (01 Mar 2021) Plants grow in two directions: the shoots of plants grow toward the light to make the best use of it, and the roots grow toward the center of the earth into the soil. A team has now been able to describe in detail how the molecular mechanisms work that control these processes.

Hotter, drier, CRISPR: editing for climate change (01 Mar 2021)
Just 15 plant crops provide 90 per cent of the world's food calories. A review of genome editing technologies states gene editing technology could play a vital role to play in climate-proofing future crops to protect global food security. The review recommends integrating CRISPR-Cas9 genome editing into modern breeding programs for crop improvement [+]


Identified: A mechanism that protects plant fertility from stress (01 Mar 2021) As temperatures rise due to global warming the need to protect plants from stressful conditions has increased, as stress can cause a loss in yield and cause further impact economically. Researchers have successfully identified two proteins that protect crops from stress, which is key in safeguarding food production.

Searching for novel targets for new antibiotics (01 Mar 2021)
Ribosome formation is viewed as a promising potential target for new antibacterial agents. Researchers have gained new insights into this multifaceted process. The formation of ribosomal components involves multiple helper proteins which, much like instruments in an orchestra, interact in a coordinated way. One of these helper proteins - protein Ob [+]


Measuring the tRNA world (26 Feb 2021)
Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology, but measuring the amount of each tRNA in cells has been limited by technical challenges. Researchers have now overcome these limitations with mim-tRNAseq, [+]


Maternal instincts lead to social life of bees (26 Feb 2021)
The maternal care of offspring is one of the behavioral drivers that has led some bee species to have an ever-expanding social life over the history of evolution, new research has found. By virtue of being in a social group the genome itself may respond by selecting more social, rather than non-social genes. The behavior and social environment come [+]


Retroviruses are re-writing the koala genome and causing cancer (26 Feb 2021)
Koalas are facing multiple environmental and health issues which threaten their survival. Along with habitat loss - accelerated by last year's devastating bush fires - domestic dog attacks and road accidents, they suffer from deadly chlamydial infections and extremely high frequency of cancer. Scientists now demonstrate that a retrovirus invading t [+]


Signal transduction without signal: Receptor clusters can direct cell movement (25 Feb 2021)
Whether we smell, taste or see, or when adrenaline rushes through our veins, all of these signals are received by our cells via a specific group of receptor proteins called G protein-coupled receptors, which transmit signals to the inside of the cell. Biochemists have now discovered that such receptors can also produce signals even in the absence o [+]


First complete coronavirus model shows cooperation (25 Feb 2021)
Multiscale coarse-grained model of complete SARS-CoV-2 virion developed for first time using supercomputers. Cooperative motion of coronavirus spike protein simulations likely informative of how virus explores and detects ACE2 receptors of potential host cell. Frontera supercomputer at TACC generated all-atom simulations of coronavirus spike protei [+]


How plant stem cells renew themselves -- a cytokinin story (25 Feb 2021) Biologists have discovered how cytokinin activates stem cell division in plants.

Super-resolution RNA imaging in live cells (25 Feb 2021)
Ribonucleic acid (RNA) is key to various fundamental biological processes. It transfers genetic information, translates it into proteins or supports gene regulation. To achieve a more detailed understanding of the precise functions it performs, researchers have devised a new fluorescence imaging method which enables live-cell RNA imaging with unpre [+]


'Miracle poison' for novel therapeutics (25 Feb 2021) Researchers demonstrate they can engineer botulinum toxin proteins (called proteases) to find new targets with high selectivity, a critical advance toward potential new treatments for everything from neuroregeneration to cytokine storm.

Sulfur metabolism may have paved the way for evolution of multicellularity (24 Feb 2021)
When the slime mold Dictyostelium discoideum runs out of food, sulfur limitation drives its development from a unicellular to a multicellular organism. Researchers now present the nutrient signaling pathways in this early eukaryote in great detail. Their results show how metabolism may have played a crucial role in the origins of multicellularity. [+]


Cancer research to gain from identification of 300 proteins that regulate cell division (24 Feb 2021) With the hope of contributing to the fight against cancer, researchers in Sweden have published a new molecular mapping of proteins that regulate the cell division process - identifying 300 such proteins.

New gene-editing tool allows for programming of sequential edits over time (23 Feb 2021) Researchers have discovered a new gene-editing technique that allows for the programming of sequential cuts -- or edits -- over time.

New features of a gene defect that affects muzzle length and caudal vertebrae in dogs (23 Feb 2021)
A recent genetic study provides new information on the occurrence of a DVL2 gene defect associated with a screw tail and its relevance to canine constitution and health. The variant was found in several Bulldog and Pit Bull type breeds, and it was shown to result in caudal vertebral anomalies and shortening of the muzzle. The DLV2 variant may also [+]


Don't focus on genetic diversity to save our species (23 Feb 2021) Scientists have challenged the common assumption that genetic diversity of a species is a key indicator of extinction risk. The scientists demonstrate that there is no simple relationship between genetic diversity and species survival. But researchers conclude the focus shouldn't be on genetic diversity anyway; it should be on habitat protection.

Scientists use DNA origami to monitor CRISPR gene targeting (23 Feb 2021) The remarkable genetic scissors called CRISPR/Cas9, the discovery that won the 2020 Nobel Prize in Chemistry, sometimes cut in places that they are not designed to target.

Tweaking corn kernels with CRISPR (22 Feb 2021) Corn has a highly complex genome, making it a challenge to apply genome-editing techniques to it. Researchers used CRISPR to tinker with the corn genome promoter regions and modify stem cell growth. They figured out which sections influence kernel yield, and they hope to make targeted genome-editing in corn more precise and efficient.

Study could explain tuberculosis bacteria paradox (22 Feb 2021) Tuberculosis bacteria have evolved to remember stressful encounters and react quickly to future stress, according to a study by computational bioengineers and infectious disease experts.

 


  

Noticias sobre Genética | EL PAÍS

 

Genética cotidiana (Prof. José Luis Micol Molina) 

 
Selección de noticias sobre genética aparecida en medios de comunicación español, y se añade un breve comentario. Se incluye un enlace a la noticia en español y cuando es posible, otro al artículo científico original en inglés. (Prof. José Luis Micol Molina, Catedrático de Genética, Universidad Miguel Hernández)

 

Blog Genes, genomas y otras genialidades (Prof. Ana Aguirre) Universidad del País Vasco

Este blog surge del interés de la autora por la formación de los estudiantes de Grado y de posgrado del ámbito de las Biociencias. Está concebido como un complemento formativo e informativo para estudiantes universitarios y para cualquier persona interesada por conocer de cerca los avances que suceden en el campo de la Genética, de la Biología Molecular y de otras áreas afines. 

 



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Curso de Genética - Grado Genética de la UAB
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Prof. Antonio Barbadilla

 Journal Rankings on Genetics 

Biological Sciences - Genetics: 390 journals. http://journalseek.net/cgi-bin/journalseek/journalsearch.cgi?field=category&query=bio.genet

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Els éssers humans, al capdavall, no som més que un portador o un vehicle per als gens, que ens cavalquen de generació en generació com si fóssim cavalls de carreres fins a deixar-nos rendits. Els gens no pensen en què és bo o què és dolent; per a ells només som un mitjà. L'única cosa en què pensen és què és més eficaç per a ells.
Haruki Murakami

Contribuit per Laia Conchillo i Marta Pérez