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Noticiario genética


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Headline (Posted) Abstract
Grafting with epigenetically-modified rootstock yields surprise (22 Oct 2020) Novel grafted plants -- consisting of rootstock epigenetically modified to 'believe' it has been under stress -- joined to an unmodified scion, or above-ground shoot, give rise to progeny that are more vigorous, productive and resilient than the parental plants.

Genome sequencing shows climate barrier to spread of Africanized bees (21 Oct 2020) Since the 1950s, 'Africanized' honeybees have spread north and south across the Americas until apparently coming to a halt in California and northern Argentina. Now genome sequencing of hundreds of bees from the northern and southern limits shows a gradual decline in African ancestry across hundreds of miles, rather than an abrupt shift.

Delivering proteins to testes could someday treat male infertility (21 Oct 2020)
According to the Mayo Clinic, about 15% of couples are infertile, and male infertility plays a role in over one-third of these cases. Often, problems with sperm development are to blame. Now, researchers have found a way to deliver a protein important for sperm cell production directly to mouse testicles, where it restored normal sperm development [+]

The consequences of mating at the molecular level (21 Oct 2020)
Researchers identified a novel mechanism by which mating affects the behavior of germline stem cells (GSCs). By studying Drosophila melanogaster, the researchers showed that the neurons that are activated during mating result in increased intracellular calcium signaling in cells adjacent to GSCs, which in turn resulted in the activation of the prot [+]

Transcription factors may inadvertently lock in DNA mistakes (21 Oct 2020)
A team of researchers has found that transcription factors have a tendency to bind strongly to 'mismatched' sections of DNA, i.e. sections of the genome that were not copied correctly. The strong binding of transcription factors to these mismatched sections of regulatory DNA might be a way in which random mutations become a problem that leads to di [+]

Repairing the photosynthetic enzyme Rubisco (20 Oct 2020) Researchers have elucidated how Rubisco activase works. As the name indicates, this enzyme is critical for repairing Rubisco once it has lost its activity.

Targeting the shell of the Ebola virus (20 Oct 2020)
As the world grapples with COVID-19, the Ebola virus is again raging. Researchers are using supercomputers to simulate the inner workings of Ebola (as well as COVID-19), looking at how molecules move, atom by atom, to carry out their functions. Now, they have revealed structural features of the Ebola virus's protein shell to provide therapeutic tar [+]

The road to uncovering a novel mechanism for disposing of misfolded proteins (20 Oct 2020) The discovery of the cause of a rare liver disease in babies led to uncovering a novel cellular mechanism for disposing of misfolded proteins that has implications for neurodegenerative conditions of older age.

Childlessness by circumstance (20 Oct 2020)
In birds and other species alike, pairs can face considerable difficulties with reproduction. Scientists have now shown in an extensive analysis of 23,000 zebra finch eggs that infertility is mainly due to males, while high embryo mortality is more a problem of the females. Inbreeding, age of the parents and conditions experienced when growing up h [+]

CRISPR meets Pac-Man: New DNA cut-and-paste tool enables bigger gene edits (20 Oct 2020) Gene editing for the development of new treatments, and for studying disease as well as normal function in humans and other organisms, may advance more quickly with a new tool for cutting larger pieces of DNA out of a cell's genome, according to a new study.

Plants communicate at a molecular level (20 Oct 2020) Biologists have discovered how tomato plants identify Cuscuta as a parasite. The plant has a protein in its cell walls that is identified as 'foreign' by a receptor in the tomato.

Management of a popular game fish, the smallmouth bass (19 Oct 2020)
For recreational fishing enthusiasts, the thrill of snagging their next catch comes with discovering what's hooked on the end of the line. In many freshwater streams and rivers -- across the central and eastern parts of the U.S. -- anglers are often catching a popular freshwater game fish: the smallmouth bass. Now, scientists have discovered a new [+]

Prebiotic chemistry: In the beginning, there was sugar (19 Oct 2020) Organic molecules formed the basis for the evolution of life. But how could inorganic precursors have given rise to them? Chemists now reports a reaction pathway in which minerals catalyze the formation of sugars in the absence of water.

AI methods of analyzing social networks find new cell types in tissue (19 Oct 2020)
In situ sequencing enables gene activity inside body tissues to be depicted in microscope images. To facilitate interpretation of the vast quantities of information generated. Researchers have now developed an entirely new method of image analysis. Based on algorithms used in artificial intelligence, the method was originally devised to enhance und [+]

Pinpointing the 'silent' mutations that gave the coronavirus an evolutionary edge (16 Oct 2020) Researchers have identified a number of 'silent' mutations in the roughly 30,000 letters of the COVID-19 virus's genetic code that helped it thrive once it made the leap from bats and other wildlife to humans -- and possibly helped set the stage for the global pandemic.

Ingestible capsule that could help demystify the gut-brain axis (15 Oct 2020) A team of experts from engineering, neuroscience, applied microbiology, and physics has been making headway on building a platform that can monitor and model the real-time processing of gut microbiome serotonin activity.

Supergene discovery leads to new knowledge of fire ants (15 Oct 2020) A unique study conducted by entomologists led to the discovery of a distinctive supergene in fire ant colonies that determines whether young queen ants will leave their birth colony to start their own new colony or if they will join one with multiple queens.

Machine learning uncovers potential new TB drugs (15 Oct 2020) Using a machine-learning approach that incorporates uncertainty, researchers identified several promising compounds that target a protein required for the survival of the bacteria that cause tuberculosis.

Why do identical cells act differently? Team unravels sources of cellular 'noise' (14 Oct 2020) Researchers have taken an important step toward explaining why genetically identical cells can produce varying amounts of the same protein associated with the same gene. Researchers demonstrated that most of the fluctuations in gene expression between identical cells occur in the first step of protein production, called transcription.

Virus-mimicking drug helps immune system target cunning cancer cells (14 Oct 2020) Researchers found that a drug that activates the body's natural defenses by behaving like a virus may also make certain stealthy melanoma tumors visible to the immune system, allowing them to be better targeted by immunotherapy.

DNA-peptide interactions create complex behaviors which may have helped shape biology (14 Oct 2020) Researchers find that simple DNA-peptide interactions create a surprising diversity of compartmentalized higher-ordered phase behaviors, suggesting that these polymers' primordial interactions helped create modern complex biological structures.

Seeing evolution happening before your eyes (14 Oct 2020) Researchers have established an automated pipeline to create mutations in genomic enhancers that let them watch evolution unfold before their eyes. Their findings on fruit flies may also be relevant to the understanding of human diseases, requiring researchers to reassess assumptions about how enhancers contribute to human health.

The atomic makeup of M. pneumoniae's 'nap' structure glides into view (14 Oct 2020)
Using X-ray crystallography and cryo-electron microscopy, an international team of scientists unravel the atomic structure of the proteins P1 and P40/P90 which make up the 'Nap' structure - a protein complex that the bacterium M. pneumoniae uses to attach and move around human cells to cause pneumonia. This will allow us to better understand the '' [+]

Molecular dance keeps your heart beating (14 Oct 2020) New research demonstrates a molecular dance that keeps your heart beating. The findings could someday lead to improved diagnostics and medical treatments for serious and sometimes devastating hereditary heart conditions.

Bacterial toxin with healing effect (13 Oct 2020) A bacterial toxin promoting tissue healing has been discovered. The compound, found in Staphylococcus aureus, does not just damage cells, but also stimulates tissue regeneration.

Mechanism that restores cell function after genome damage (13 Oct 2020) Researchers have found out how cells can recover their development and longevity after damage by UV. The discovery may enable new therapies against premature aging.

Computer model uses virus 'appearance' to better predict winter flu strains (13 Oct 2020) Combining genetic and experimental data into models about the influenza virus can help predict more accurately which strains will be most common during the next winter, says a study published recently in eLife.

Dueling proteins give shape to plants (12 Oct 2020) In order to thrive, plants must integrate a variety of sometimes-subtle signals in their environment, from day length to nutrient presence. Biologists have unpacked how two competing proteins help plants do that. The antagonistic relationship helps dictate where and when plants develop flowers, a crucial aspect of food production in crop species.

Planting parasites: Unveiling common molecular mechanisms of parasitism and grafting (10 Oct 2020) Using the model Orobanchaceae parasitic plant Phtheirospermum japonicum, scientists have discerned the molecular mechanisms underlying plant parasitism and cross-species grafting, pinpointing one specific enzyme. Targeting this enzyme may help control plant parasitism in crops.

Quality control mechanism closes the protein production 'on-ramps' (08 Oct 2020) Recent work revealed a newfound quality control system in the protein production assembly line with possible implications for understanding neurogenerative disease.

Moles: Intersexual and genetically doped (08 Oct 2020) Female moles not only have ovarian, but also testicular tissue that produces male sex hormones - which lets them diverge from the categorization into two sexes. A team describes which genetic modifications contribute to this singular development.

New model may explain rarity of certain malaria-blocking mutations (08 Oct 2020) A new computational model suggests that certain mutations that block infection by the most dangerous species of malaria have not become widespread in people because of the parasite's effects on the immune system.

There's a gene for detecting that fishy smell, olfactory GWAS shows (08 Oct 2020)
Some people carry a mutation in a particular gene that makes the smell of fish less intense. The study, which is the largest genome-wide association study (GWAS) of olfactory genes in humans involving a sniff test and looked at over 9,000 people from Iceland, also shows that people vary in their ability to discern the smell of licorice and cinnamon [+]

HIV up close: Unprecedented view of virus reveals essential steps for causing AIDS (08 Oct 2020)
Accomplishing a feat that had been a pipe dream for decades, scientists have recreated in a test tube the first steps of infection by HIV (human immunodeficiency virus), the virus that causes AIDS (acquired immunodeficiency syndrome). Doing so has provided up-close access to the virus -- which is otherwise obstructed from view deep within the cell [+]

Setting a TRAP for pandemic-causing viruses (08 Oct 2020) A new laboratory technique quickly sifts through trillions of synthetic proteins to find ones that can target viruses, helping healthcare authorities rapidly respond to evolving pandemics.

Understanding the progress of viral infections (08 Oct 2020) Researchers have created a viral expression model that can be used to simulate and analyze a large number of viral infections -- including the one with SARS-CoV-2.

How an egg cell's 'operating manual' sets the stage for fertility (08 Oct 2020) Scientists have revealed in unprecedented detail the genetic instructions immature egg cells go through step by step as they mature into functionality. Their findings improve our understanding of how ovaries maintain a female's fertility.

Taking sides: Factors that influence patterns in protein distribution (08 Oct 2020) A new article has found that even cells in isolation can become polarized to create the head to tail pattern, and that this polarity can orient how the cell grows.

Genomic study reveals evolutionary secrets of banyan tree (08 Oct 2020)
The banyan fig tree Ficus microcarpa is famous for its aerial roots, which sprout from branches and eventually reach the soil. The tree also has a unique relationship with a wasp that has coevolved with it and is the only insect that can pollinate it. In a new study, researchers identify regions in the banyan fig's genome that promote the developme [+]

Researchers develop tools to sharpen 3D view of large RNA molecules (07 Oct 2020)
Scientists developed a method for generating high resolution 3D images of RNA, overcoming challenges limiting 3D analysis and imaging of RNA to only small molecules and pieces of RNA for the past 50 years. The new method, which expands the scope of nuclear magnetic resonance (NMR) spectroscopy, will enable researchers to understand the shape and st [+]



Noticias sobre Genética | EL PAÍS


Genética cotidiana (Prof. José Luis Micol Molina) 

Selección de noticias sobre genética aparecida en medios de comunicación español, y se añade un breve comentario. Se incluye un enlace a la noticia en español y cuando es posible, otro al artículo científico original en inglés. (Prof. José Luis Micol Molina, Catedrático de Genética, Universidad Miguel Hernández)


Blog Genes, genomas y otras genialidades (Prof. Ana Aguirre) Universidad del País Vasco

Este blog surge del interés de la autora por la formación de los estudiantes de Grado y de posgrado del ámbito de las Biociencias. Está concebido como un complemento formativo e informativo para estudiantes universitarios y para cualquier persona interesada por conocer de cerca los avances que suceden en el campo de la Genética, de la Biología Molecular y de otras áreas afines. 


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"I'm fascinated by the idea that genetics is digital. A gene is a long sequence of coded letters, like computer information. Modern biology is becoming very much a branch of information technology"
-Richard Dawkins
Contributed by Ilse Alejandra Zepeda Aceves

Genoma: nuestra propia tragicomedia con cuatro únicos personajes, ácidos. El genoma es el teatro que cada uno de nosotros representa y ensaya en una eternidad de ¡bis! Las infinitas funciones de cada una de nuestras células crea el teatro genético de nuestro yo. El ADN es el micro-ordenador de nuestro macro-cerebro infra-utilizado por ser super-desconocido. En este escenario encerramos el Gran Teatro del Mundo y el de nuestra existencia
Fernando Arrabal
Contributed by Maria Hernández Sánchez