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Noticiario genética

            

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Headline (Posted) Abstract
Most dog breeds highly inbred (02 Dec 2021) The majority of dog breeds are highly inbred, contributing to an increase in disease and health care costs throughout their lifespan, according to new research.

Researchers attacking menacing ‘superbug’ (02 Dec 2021)
Scientists around the world have been working in earnest to improve understanding of an increasingly virulent superbug, Clostridium difficile. The highly contagious hospital-acquired pathogen, designated by the Centers for Disease Control and Prevention as one of the five most urgent threats to the U.S. healthcare system, causes more than 500,000 i [+]


Harnessing the organization of the cell surface (02 Dec 2021) Scientists have developed a new method to determine how proteins are organized on the surface of cells. Insights gained with the technology could lead to the development of novel drugs to fight cancer.

Plant pathogen evades immune system by targeting the microbiome (02 Dec 2021) Biologists have discovered how a pathogenic fungus can bypass the immune system of plants. By releasing an 'effector' molecule, it avoids elimination at a critical stage in its reproduction cycle.

Scientists pinpoint protein’s role in critical gene expression (02 Dec 2021) New research has implications for cancer research because it explains part of the paradox for how cells can transcribe genes in the absence of high-energy sources, a situation that unfolds in cancer and has puzzled researchers for years.

Within an Antarctic sea squirt, scientists discover a bacterial species with promising anti-melanoma properties (01 Dec 2021) Biologists have successfully traced a naturally-produced melanoma-fighting compound called 'palmerolide A' to its source: a microbe that resides within Synoicum adareanum, a species of ascidian common to the waters of Antarctica's Anvers Island archipelago.

Researchers identify key RNA 'gatekeeper' in gene expression, pointing to possible new drug targets (01 Dec 2021) Researchers have identified the first non-coding RNA that controls formation of chromosome loops, which govern gene expression. Jpx RNA was previously thought to be involved only in X chromosome inactivation, a necessary step in development of female embryos. This discovery could create new targets for drug developers.

Deep learning dreams up new protein structures (01 Dec 2021)
Using artificial intelligence and deep learning, researchers have developed a neural network that 'hallucinates' the structures of new protein molecules. The scientists made up completely random protein sequences and introduced mutations into them until the neural network predicted they would fold into stable structures. The software was not guided [+]


Biosensor barcodes identify, detail ‘chatting’ among cancer cells (30 Nov 2021)
Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials. Scientists now demonstrate how they can do the same thing at the molecular level, studying the ways cancer ce [+]


Correcting inherited gene alterations speeds up (30 Nov 2021) Researchers have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells.

Male animals are subject to stronger evolutionary pressures than females (30 Nov 2021) Male animals are subject to stronger selection pressures than females, which may allow populations to adapt to environmental change more efficiently.

Ancient lineage of algae found to include five 'cryptic' species (30 Nov 2021)
All land plants originated from a single evolutionary event when freshwater algae got a foothold on land. The group of algae that would later give rise to land plants had already been living in freshwater and terrestrial habitats for over one billion years. A tiny group of these algae, most distantly related to land plants, still lives. A team home [+]


Parallels in human, dog oral tumors could speed new therapies (29 Nov 2021) Recent research compared the genetic expression profiles of a nonlethal canine tumor and the rare, devastating human oral tumor it resembles, laying the groundwork for potential translational medicine down the road.

Potential new therapeutic pathway to clear chronic viral infections (29 Nov 2021) A recent study in mice has uncovered that during chronic viral infection, a protein called BMI-1 gets turned on too early in B cells and messes up the delicate balance of gene expression, resulting in antibodies that are unsuccessful in their endeavor to clear the virus from the body.

Male-biased protein expression discovered in fruit flies (29 Nov 2021)
Researchers have observed a male bias in protein expression in primordial germ cells, which develop into the cells that pass on genetic material during reproduction, of the fruit fly, Drosophila. When using the Gal4-UAS system to activate expression of Green Fluorescent Protein (GFP), the team saw that male cells showed higher protein expression th [+]


Scientists produce new antibiotics by gene editing (29 Nov 2021) Scientists have discovered a new route to produce complex antibiotics exploiting gene editing to re-program pathways to future medicines urgently required to combat antimicrobial resistance, treat neglected diseases and prevent future pandemics.

Role of disordered protein interactions in gene expression (25 Nov 2021) Researchers reveal a novel mechanism that coordinates the assembly of components inside cells that control gene expression.

Unveiling the hidden cellular logistics of memory storage in neurons (24 Nov 2021) Exploring the mechanisms involved in sleep-dependent memory storage, a team of cellular biologists found that RNAs associated with an understudied cell compartment in hippocampal neurons vary greatly between sleeping and sleep-deprived mice after learning.

How molecular clusters in the nucleus interact with chromosomes (24 Nov 2021) Using computer simulations, chemists have discovered how nuclear bodies called nucleoli interact with chromosomes in the nucleus, and how those interactions help the nucleoli exist as stable droplets within the nucleus.

Endangered deer's prion gene could protect it from chronic wasting disease (24 Nov 2021)
China's Père David's deer was nearly gone in the late 1800s. Just 18 deer -- the very last of their kind -- were brought into captivity after the rest had been hunted to extinction. When 11 of the deer reproduced, the species had a chance. Today, after centuries of reintroductions and breeding under human care, the population sits at around 3,000. [+]


Unsung gene is key to how antibodies develop, study finds (24 Nov 2021) Researchers have discovered that an overlooked gene plays a major role in the development of antibodies, which help the immune system recognize and fight viruses including SARS-CoV-2, bacteria and other causes of infectious disease.

We might not know half of what’s in our cells, new AI technique reveals (24 Nov 2021) Artificial intelligence-based technique reveals previously unknown cell components that may provide new clues to human development and disease.

Microbes can provide sustainable hydrocarbons for the petrochemical industry (23 Nov 2021)
The petrochemical industry turns oil and gas into precursors used to synthesize lubricants and other critical products. Chemists show that bacteria can be metabolically engineered to generate similar precursors, providing a sustainable replacement for fossil fuels and using less energy. The microbes need only glucose. The medium-chain hydrocarbons [+]


Research sheds new light on effects of dietary restriction (23 Nov 2021) New research in the tiny nematode worm, C. elegans, has revealed that muscle may be a protected tissue under conditions of dietary restriction.

SARS-CoV-2 infection hijacks key cellular process, autophagy researchers discover (22 Nov 2021) Novel autophagy research traces new mammalian pathways and reveals unexpected impact of SARS-CoV-2 infection.

How to eat a poison butterfly (22 Nov 2021) In high enough concentrations, milkweed can kill a horse, or a human. To be able to eat this plant, monarchs evolved a set of unusual cellular mutations. New research shows the animals that prey on monarchs also evolved these same mutations.

Tracing mechanisms of large exon splicing during vertebrate evolution (20 Nov 2021)
In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists have recently identified the mechanism behind regulated splicing of large constitutive exons which are rich in disordered regions, and their potential involvement in the assembly of transcription factors. They also explained how dual-regulation by tw [+]


Novel artificial genomic DNA can replicate and evolve outside the cell (19 Nov 2021)
Scientists successfully induced gene expression from a DNA and evolution through continuous replication extracellularly using cell-free materials alone for the first time. By adding the genes necessary for transcription and translation to the artificial genomic DNA, it could be possible to develop artificial cells that can grow autonomously, and it [+]


New link between diet, intestinal stem cells and disease discovered (19 Nov 2021) Obesity, diabetes and gastrointestinal cancer are frequently linked to an unhealthy diet. However, the molecular mechanisms responsible for this are not fully understood. Researchers have gained some new insights that help to better understand this connection. These findings provide an important basis for the development of non-invasive therapies.

Phages kill dystentery-causing bacteria and reduce virulence in surviving bacteria (19 Nov 2021)
Phages are viruses that infect bacteria and can also be used to treat human infections. However, as with antibiotics, bacteria can readily evolve resistance to phage attack, highlighting a key limitation to the use of phages as therapeutics. Now, researchers have shown that the naturally occurring phage A1-1 kills Shigella flexneri, a major cause o [+]


Breeding plants with genes from one parent (19 Nov 2021) Scientists are a step closer to breeding plants with genes from only one parent. New research led by plant biologists at UC Davis shows the underlying mechanism behind eliminating half the genome and could make for easier and more rapid breeding of crop plants with desirable traits such as disease resistance.

Scientists solve 50-year-old mystery behind plant growth (18 Nov 2021) A team of researchers has demonstrated for the first time one way that a small molecule turns a single cell into something as large as a tree. For half a century, scientists have known that all plants depend on this molecule, auxin, to grow. Until now, they didn't understand exactly how auxin sets growth in motion.

Live long and prosper: Study examines genetic gems in Galápagos giant tortoise genomes (18 Nov 2021)
Galápagos giant tortoises can weigh well over 300 pounds and often live over 100 years. So what's the secret to their evolutionary success? A new study concludes that compared with other turtles, these animals evolved to have extra copies of genes -- called duplications -- that may protect against the ravages of aging, including cancer. Laboratory [+]


New cell database paints fuller picture of muscle repair (18 Nov 2021) Biologists have struggled to study rare and transient muscle cells involved in the process, but engineers have lifted the curtain on these elusive dynamics with the launch of scMuscle, one of the largest single-cell databases of its kind.

How do we know we're tired? (18 Nov 2021) Why do we need sleep? New research takes a step towards solving this mystery by discovering a mechanism of sleep in zebrafish, with some supporting evidence in mice.

How cells feel curvature (18 Nov 2021) Cells in your body cannot see, but they can feel their surroundings and their own shape. Scientists now showed via both - experiments and theory - how cells can sense the curvature of tissue around them and how this influences their inner workings.

Breakthrough in fight on tick-borne CCHF virus is latest use of new strategy against diseases (18 Nov 2021) Using the same approach they recently used to create effective vaccine candidates against COVID-19 and respiratory syncytial virus (RSV), scientists are tackling another virus: the tick-borne Crimean-Congo hemorrhagic fever (CCHF).

New findings on the link between CRISPR gene-editing and mutated cancer cells (18 Nov 2021)
A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers have found new links between CRISPR, p53 and other cancer genes that could prevent the accumulation of mutated cells without compromising [+]


Study links stress to Crohn’s disease flare-ups (18 Nov 2021) Researchers using mouse models found that stress hormones suppressed the innate immune system that normally protects the gut from invasive Enterobacteriaceae, a group of bacteria including E. coli which has been linked to Crohn's disease.

Scientist advances prospect of regeneration in humans (17 Nov 2021)
In a study that builds on earlier research that identified macrophages as essential to regeneration in the axolotl, a highly regenerative salamander, a scientist has identified the source of these critical white blood cells as the liver. By giving scientists a place to look for pro-regenerative macrophages in humans, the discovery brings science a [+]


 


  

Noticias sobre Genética | EL PAÍS

 

Genética cotidiana (Prof. José Luis Micol Molina) 

 
Selección de noticias sobre genética aparecida en medios de comunicación español, y se añade un breve comentario. Se incluye un enlace a la noticia en español y cuando es posible, otro al artículo científico original en inglés. (Prof. José Luis Micol Molina, Catedrático de Genética, Universidad Miguel Hernández)

 

Blog Genes, genomas y otras genialidades (Prof. Ana Aguirre) Universidad del País Vasco

Este blog surge del interés de la autora por la formación de los estudiantes de Grado y de posgrado del ámbito de las Biociencias. Está concebido como un complemento formativo e informativo para estudiantes universitarios y para cualquier persona interesada por conocer de cerca los avances que suceden en el campo de la Genética, de la Biología Molecular y de otras áreas afines. 

 



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